{"id":968,"date":"2020-10-31T11:27:35","date_gmt":"2020-10-31T02:27:35","guid":{"rendered":"https:\/\/info.zanet.biz\/?p=968"},"modified":"2020-10-31T14:23:25","modified_gmt":"2020-10-31T05:23:25","slug":"%e4%ba%a4%e7%b5%a1%e5%9b%a0%e5%ad%90confounders","status":"publish","type":"post","link":"https:\/\/info.zanet.biz\/?p=968","title":{"rendered":"\u4ea4\u7d61\u56e0\u5b50Confounders"},"content":{"rendered":"\n<p>\u75ab\u5b66Epidemiology\u3068\u81e8\u5e8a\u75ab\u5b66Clinical Epidemiology\u306f\u540c\u3058\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u524d\u8005\u306e\u65b9\u304c\u6b74\u53f2\u304c\u9577\u304f\u3001\u975e\u5e38\u306b\u5965\u304c\u6df1\u3044\u9818\u57df\u3067\u3059\u3002Evidence-Based Medicine (EBM)\u306b\u8208\u5473\u3092\u6301\u3063\u3066\u3001\u7814\u7a76\u306e\u5185\u7684\u59a5\u5f53\u6027\u306e\u8a55\u4fa1\u3001\u3044\u308f\u3086\u308b\u6279\u5224\u7684\u541f\u5473Critical appraisal\u3092\u5b66\u3093\u3060\u3068\u3057\u3066\u3082\u3001\u75ab\u5b66\u306e\u5965\u6df1\u3055\u306b\u306f\u306a\u304b\u306a\u304b\u5230\u9054\u3067\u304d\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Rothman KJ, Greenland S, Lash TL: Modern Epidemiology (3rd ed.) 2008 Lippincott Williams &amp; Wilkins. PA, USA.\u306e\u306f\u767a\u520a\u3055\u308c\u3066\u304b\u308910\u5e74\u4ee5\u4e0a\u7d4c\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u4eca\u3067\u3082\u975e\u5e38\u306b\u512a\u308c\u305f\u75ab\u5b66\u306e\u30c6\u30ad\u30b9\u30c8\u30d6\u30c3\u30af\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u3053\u306eChapter 9. Validity in Epidemiologic Studies.&nbsp;Rothman KJ, Greenland S, Lash TL\u3067\u306fValidity of Estimation\u63a8\u5b9a\u5024\u306e\u59a5\u5f53\u6027\u3001Confounding\u4ea4\u7d61\u3001Selection Bias\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u3001Information Bias\u60c5\u5831\u30d0\u30a4\u30a2\u30b9\u3001Generalizability\u4e00\u822c\u5316\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4ea4\u7d61\u56e0\u5b50\u306f\u66dd\u9732\/\u4ecb\u5165\u3068\u3082\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u3082\u95a2\u9023\u306e\u3042\u308b\u56e0\u5b50\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u98f2\u9152\u8005\u3068\u975e\u98f2\u9152\u8005\u3067\u53e3\u8154\u764c\u306e\u767a\u75c7\u3092\u6bd4\u8f03\u3059\u308b\u5834\u5408\u3001\u98f2\u9152\u3059\u308b\u4eba\u306f\u55ab\u7159\u3059\u308b\u4eba\u304c\u591a\u304f\u3001\u55ab\u7159\u306f\u53e3\u8154\u764c\u306e\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u3067\u3042\u308a\u3001\u55ab\u7159\u306f\u98f2\u9152\u3068\u53e3\u8154\u764c\u767a\u75c7\u767a\u75c7\u306e\u4e21\u65b9\u306b\u95a2\u9023\u304c\u3042\u308b\u305f\u3081\u3001\u4ea4\u7d61\u56e0\u5b50\u3067\u3042\u308a\u3001\u98f2\u9152\u306e\u53e3\u8154\u764c\u767a\u75c7\u3078\u306e\u52b9\u679c\u3092\u6b6a\u3081\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>Counterfactual\u53cd\u4e8b\u5b9f\u306e\u5bfe\u7167\u3092\u8a2d\u5b9a\u3067\u304d\u306a\u3044\u9650\u308a\u3001\u5bfe\u7167\u7fa4\u3068\u66b4\u9732\u7fa4\u306e\u6bd4\u8f03\u3067\u306f\u4ea4\u7d61\u306e\u5f71\u97ff\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u5fc5\u9808\u3060\u3068\u8a00\u3048\u307e\u3059\uff08\u6700\u5f8c\u306e\u8ffd\u52a0\u3092\u898b\u3066\u304f\u3060\u3055\u3044\uff09\u3002<\/p>\n\n\n\n<p>Rothman KJ\u3089\u306f\u4e0a\u8a18\u306e\u7b2c9\u7ae0\u3067\u3001\u4ea4\u7d61\u56e0\u5b50\u306b\u3064\u3044\u3066\u306f3\u3064\u306e\u57fa\u6e96Criteria\u304c\u3042\u308b\u3053\u3068\u3092\u8ff0\u3079\u3066\u3044\u307e\u3059\uff08\u56f31\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/10\/confounders-3-criteria-1024x501.png\" alt=\"\" class=\"wp-image-969\" width=\"512\" height=\"251\" srcset=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/10\/confounders-3-criteria-1024x501.png 1024w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/10\/confounders-3-criteria-300x147.png 300w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/10\/confounders-3-criteria-768x376.png 768w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/10\/confounders-3-criteria.png 1196w\" sizes=\"auto, (max-width: 512px) 85vw, 512px\" \/><figcaption>\u56f31\uff0e\u4ea4\u7d61\u56e0\u5b50\u306e3\u57fa\u6e96\u3002<\/figcaption><\/figure>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e3\u3064\u306e\u7279\u5fb4\u304c\u4ea4\u7d61\u56e0\u5b50\u306e\u5b9a\u7fa9\u3068\u3057\u3066\u8aa4\u89e3\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3053\u3068\u3001\u3053\u3053\u308c\u3089\u306e\u57fa\u6e96\u304c\u6e80\u305f\u3055\u308c\u3066\u3082\u5fc5\u305a\u4ea4\u7d61\u56e0\u5b50\u3068\u8a00\u3048\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u539f\u56e0\u3068\u306a\u308b\u5916\u90e8\u56e0\u5b50\u3068\u95a2\u9023\u304c\u3042\u308a\u3001\u305d\u306e\u4ee3\u7406\u3068\u306a\u308a\u3046\u308b\u56e0\u5b50\u3082\u4ea4\u7d61\u56e0\u5b50\u3068\u547c\u3070\u308c\u308b\u3002\u3059\u306a\u308f\u3061\u3001\u4ee3\u7406\u4ea4\u7d61\u56e0\u5b50Surrogate confounder\u304c\u5358\u306b\u4ea4\u7d61\u56e0\u5b50\u3068\u547c\u3070\u308c\u308b\u3053\u3068\u3082\u591a\u3044\u3068\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u591a\u304f\u306e\u7814\u7a76\u3067\u5e74\u9f62\u304c\u4ea4\u7d61\u56e0\u5b50\u3068\u3057\u3066\u53d6\u308a\u6271\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5e74\u9f62\u306f\u4ee3\u7406\u4ea4\u7d61\u56e0\u5b50\u306e\u4ee3\u8868\u7684\u306a\u3082\u306e\u3067\u3059\u3002\u52a0\u9f62\u306b\u3088\u3063\u3066\u8d77\u304d\u308b\u3001\u7d30\u80de\u306e\u5909\u7570\u306e\u84c4\u7a4d\u3001\u7d44\u7e54\u306e\u640d\u50b7\u306e\u84c4\u7a4d\u306a\u3069\u304c\u75be\u60a3\u767a\u75c7\uff08\u30a2\u30a6\u30c8\u30ab\u30e0\uff09\u306e\u539f\u56e0\u3067\u3042\u3063\u3066\u3001\u5e74\u9f62\u81ea\u4f53\u304c\u75be\u60a3\u767a\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u308f\u3051\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e3\u6761\u4ef6\u306b\u3064\u3044\u3066\u306e\u5f7c\u3089\u306e\u8a18\u8ff0\u3092\u30ea\u30b9\u30c8\u30a2\u30c3\u30d7\u3057\u3066\u307f\u307e\u3059\uff1a<\/p>\n\n\n\n<p>\u30fb\u4ea4\u7d61\u56e0\u5b50\u3001\u4ee3\u7406\u4ea4\u7d61\u56e0\u5b50\u306e\u3044\u305a\u308c\u3067\u3082\u3001\u4ea4\u7d61\u56e0\u5b50\u5019\u88dc\u3068\u3057\u3066\u6271\u3063\u3066\u3044\u3044\u304c\u3001\u7814\u7a76\u4e0b\u306e\u66b4\u9732\u306e\u305d\u306e\u30ec\u30d9\u30eb\u3067\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u3082\u306e\u3067\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002<br>\u30fb\u30c7\u30fc\u30bf\u3067\u8a8d\u3081\u3089\u308c\u308b\u4ea4\u7d61\u56e0\u5b50\u5019\u88dc\u3068\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u95a2\u9023\u306f\u4ea4\u7d61\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u898b\u6975\u3081\u308b\u30ac\u30a4\u30c9\u306b\u306a\u308b\u304c\u3001\u898b\u304b\u3051\u4e0a\u306e\u95a2\u9023\u3067\u306a\u304f\u3001\u5b9f\u969b\u306e\u95a2\u9023\u3067\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002<br>\u30fb\u4ea4\u7d61\u56e0\u5b50\u5019\u88dc\u3068\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u95a2\u9023\u3092\u77e5\u308b\u306b\u306f\u5916\u90e8\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3001\u3059\u306a\u308f\u3061\u4e8b\u524d\u306e\u77e5\u8b58Prior knowledge\u304c\u5fc5\u8981\u306b\u306a\u308a\u3001\u7279\u306b\u5c0f\u898f\u6a21\u306a\u7814\u7a76\u306e\u5834\u5408\u306f\u305d\u3046\u3067\u3042\u308b\u3002<br>\u30fb\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5916\u90e8\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u9650\u754c\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<br>\u30fb\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u306f\u539f\u96c6\u56e3Source population\u306f\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u306b\u306a\u308a\u3001\u6e2c\u5b9a\u8aa4\u5dee\u304c\u7121\u3051\u308c\u3070\u3001\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u3067\u66b4\u9732\u3068\u95a2\u9023\u306e\u3042\u308b\u56e0\u5b50\u306f\u4ea4\u7d61\u56e0\u5b50\u3068\u8003\u3048\u3066\u3088\u3044\u3002<br>\u30fb\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u3042\u308c\u3070\u4ea4\u7d61\u304c\u8d77\u304d\u306a\u3044\u3068\u306f\u8a00\u3048\u306a\u3044\u3002\u5c0f\u898f\u6a21\u306a\u8a66\u9a13\u306e\u5834\u5408\u306f\u5927\u304d\u304f\u306a\u308a\u3084\u3059\u304f\u3001\u5927\u898f\u6a21\u306a\u8a66\u9a13\u3067\u3042\u3063\u3066\u3082\u4ecb\u5165\u306e\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u304c\u60aa\u3044\u5834\u5408\u3001\u8131\u843d\u304c\u591a\u3044\u5834\u5408\u306f\u4ea4\u7d61\u304c\u8d77\u304d\u3084\u3059\u3044\u3002<br>\u30fb\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3067\u306f\u539f\u96c6\u56e3\u306e\u5185\u3001\u30b1\u30fc\u30b9\u3068\u306a\u308b\u96c6\u56e3\u3067\u3001\u66b4\u9732\u3068\u4ea4\u7d61\u56e0\u5b50\u306e\u5019\u88dc\u306e\u95a2\u9023\u304c\u3042\u308b\u306f\u305a\u3067\u3042\u308b\u3002\u5bfe\u7167\u7fa4\u304c\u5341\u5206\u5927\u304d\u304f\u3001\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u30fb\u6e2c\u5b9a\u8aa4\u5dee\u304c\u7121\u3051\u308c\u3070\u3001\u7814\u7a76\u30c7\u30fc\u30bf\u304b\u3089\u4ea4\u7d61\u3092\u30c1\u30a7\u30c3\u30af\u3067\u304d\u308b\u304c\u3001\u4e00\u822c\u7684\u306b\u306f\u66b4\u9732\u3068\u4ea4\u7d61\u56e0\u5b50\u306e\u5019\u88dc\u3068\u306e\u95a2\u9023\u3092\u9069\u5207\u306b\u63a8\u5b9a\u3067\u304d\u306a\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u3002\uff08Bias analysis\u304c\u5fc5\u8981\uff09\u3002<br>\u30fb\u4ea4\u7d61\u56e0\u5b50\u304c\u66b4\u9732\u3088\u308a\u3082\u5148\u884cPrecede\u3057\u3066\u3044\u308b\u3002<br>\u30fb\u4ea4\u7d61\u56e0\u5b50\u304c\u30a2\u30a6\u30c8\u30ab\u30e0\u3088\u308a\u5148\u884c\u3057\u3066\u3044\u308b\u3002<br>\u30fb\u3082\u3057\u3001\u4ea4\u7d61\u56e0\u5b50\u5019\u88dc\u304c\u66b4\u9732\u306e\u7d50\u679c\u3067\u3042\u308a\u3001\u305d\u306e\u7d50\u679c\u304c\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u5834\u5408\uff1d\u4e2d\u9593\u56e0\u5b50\u306e\u5834\u5408\u3001\u4ea4\u7d61\u56e0\u5b50\u3068\u3057\u3066\u89e3\u6790\u3057\u306a\u3044\u3067\u3001\u4e2d\u9593\u56e0\u5b50\u3068\u3057\u3066\u89e3\u6790\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<br>\u30fb3\u6761\u4ef6\u304c\u6e80\u305f\u3055\u308c\u308b\u4ea4\u7d61\u56e0\u5b50\u304c\u540c\u5b9a\u3067\u304d\u305f\u5834\u5408\u3067\u3082\u4ed6\u306b\u672a\u77e5\u306e\u4ea4\u7d61\u56e0\u5b50\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<br>\u30fb\u672a\u77e5\u306e\u4ea4\u7d61\u56e0\u5b50\u306f\u89e3\u6790\u3067\u304d\u306a\u3044\u3002<br>\u30fb\u672a\u77e5\u306e\u4ea4\u7d61\u56e0\u5b50\u306e\u52b9\u679c\u304c\u6df7\u3056\u308a\u5408\u3063\u305f\u7d50\u679c\u304c\u30d7\u30e9\u30b9\u30de\u30a4\u30ca\u30b90\u306b\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u3046\u308b\u3002<br>\u30fb\u6761\u4ef6\u306b\u3088\u3063\u3066\u306f\u3001\u672a\u77e5\u306e\u4ea4\u7d61\u56e0\u5b50\u306e\u52b9\u679c\u3092\u66b4\u9732\u306e\u52b9\u679c\u3068\u53d6\u308a\u9055\u3048\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3055\u3066\u3001\u30d0\u30a4\u30a2\u30b9\u3084\u4ea4\u7d61\u56e0\u5b50\u3042\u308b\u3044\u306f\u4ea4\u7d61\u3068\u3044\u3046\u7528\u8a9e\u306e\u4f7f\u3044\u65b9\u306f\u4f7f\u3046\u4eba\u306b\u3088\u3063\u3066\u3055\u307e\u3056\u307e\u3067\u3042\u308b\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002Schwartz S\u3089\u306f\u3053\u306e\u6295\u7a3f\u306e\u6700\u5f8c\u306b\u793a\u3059\u8ad6\u6587\u3067\u3001Internal validity, Source population, Causal effect, Actual effect of exposure, Bias (i.e., invalidity)\u306b\u3064\u3044\u3066\u306e\u5b9a\u7fa9\u3092\u793a\u3057\u305f\u306e\u3061\u3001&#8221;<strong><u>Confounding<\/u><\/strong>, <strong><u>selection bias<\/u><\/strong>, and <strong><u>information bias<\/u><\/strong> are categories of bias thus defined. What unites them is their consequence\u2014what they do to the study results. They each create noncomparability, which prevents the identification of the true causal effect the exposure had on the exposed in the source population.&#8221;\u300c\u4ea4\u7d61\u3001\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u3001\u60c5\u5831\u30d0\u30a4\u30a2\u30b9\u306f\u3001\u3053\u306e\u3088\u3046\u306b\u5b9a\u7fa9\u3055\u308c\u305f\u30d0\u30a4\u30a2\u30b9\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u30d0\u30a4\u30a2\u30b9\u3092\u307e\u3068\u3081\u3066\u3044\u308b\u306e\u306f\u3001\u305d\u306e\u7d50\u679c\u3001\u3059\u306a\u308f\u3061\u7814\u7a76\u7d50\u679c\u306b\u4f55\u3092\u3082\u305f\u3089\u3059\u304b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u30d0\u30a4\u30a2\u30b9\u306f\u305d\u308c\u305e\u308c\u975e\u6bd4\u8f03\u53ef\u80fd\u6027\u3092\u751f\u307f\u51fa\u3057\u3001\u66b4\u9732\u304c\u539f\u96c6\u56e3\u306e\u88ab\u66b4\u9732\u8005\u306b\u4e0e\u3048\u305f\u771f\u306e\u56e0\u679c\u95a2\u4fc2\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u3092\u59a8\u3052\u308b\u3002\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7570\u306a\u308b\u8996\u70b9\u3001\u7570\u306a\u308b\u5206\u91ce\u3067\u306e\u7570\u306a\u308b\u8003\u3048\u306a\u3069\u3092\u77e5\u308b\u3053\u3068\u304c\u3068\u3066\u3082\u91cd\u8981\u306b\u601d\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6587\u732e\uff1a<br>Rothman KJ, Greenland S, Lash TL: Modern Epidemiology (3rd ed.) 2008 Lippincott Williams &amp; Wilkins. PA, USA.<br><br>Schwartz S, Campbell UB, Gatto NM, Gordon K: Toward a clarification of the taxonomy of &#8220;bias&#8221; in epidemiology textbooks.\u00a0 2015;26:216-22. doi: <a rel=\"noreferrer noopener\" href=\"https:\/\/journals.lww.com\/epidem\/Fulltext\/2015\/03000\/Toward_a_Clarification_of_the_Taxonomy_of__Bias_.14.aspx\" target=\"_blank\">10.1097\/EDE.0000000000000224<\/a> PMID: <a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25536455\/\" target=\"_blank\">25536455<\/a><\/p>\n\n\n\n<p>\u8ffd\u52a0\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><tbody><tr><td>\u52b9\u679c\u6e2c\u5b9a\u5024Measures of effect<\/td><td>\u95a2\u9023\u6e2c\u5b9a\u5024Measures of association<\/td><\/tr><tr><td>\u96c6\u56e3\u3068\u66b4\u9732\u4ee5\u5916\u306f\u540c\u3058\u53cd\u4e8b\u5b9f\u96c6\u56e3\u3092\u6bd4\u8f03\u3059\u308b\u3002<\/td><td>\u96c6\u56e3\u3068\u66b4\u9732\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u7570\u306a\u308b\u4eba\u3005\u306e\u7570\u306a\u308b\u96c6\u56e3\u3092\u6bd4\u8f03\u3059\u308b\u3002<\/td><\/tr><\/tbody><\/table><figcaption>\u52b9\u679ceffect\u3068\u95a2\u9023association\u3092\u4f7f\u3044\u5206\u3051\u3066\u3044\u307e\u3059\u3002\u672c\u5f53\u306e\u5024\u3068\u7814\u7a76\u7d50\u679c\u3067\u5f97\u3089\u308c\u305f\u5024\u3068\u8003\u3048\u3066\u3082\u3044\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/figcaption><\/figure>\n\n\n\n<p>2\u3064\u306e\u96c6\u56e3\u9593\u306e\u5dee\u304c\u898b\u3089\u308c\u3001\u3053\u308c\u30892\u3064\u306e\u6e2c\u5b9a\u5024\u3001\u3059\u306a\u308f\u3061\u52b9\u679c\u6e2c\u5b9a\u5024\u3068\u95a2\u9023\u6e2c\u5b9a\u5024\u3001\u304c\u7570\u306a\u308b\u5834\u5408\u3001\u6211\u3005\u306f\u3001\u95a2\u9023association\u304c\u4ea4\u7d61\u3057\u3066\u3044\u308bconfounded\u3001\u307e\u305f\u306f\u4ea4\u7d61\u304c\u95a2\u9023\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u3068\u8a00\u3046\u3002\u00a0 \u3053\u308c\u30892\u3064\u306e\u6e2c\u5b9a\u5024\u304c\u540c\u3058\u3067\u3042\u308c\u3070\u3001\u4ea4\u7d61\u306f\u5b58\u5728\u3057\u306a\u3044\u3068\u8a00\u3046\u3002<br><br>\u4ea4\u7d61\u56e0\u5b50\u3068\u306f\u3001\u95a2\u9023\u6027\u306e\u6e2c\u5b9a\u5024\u3068\u3001\u53cd\u4e8b\u5b9fcounterfactulal\u306e\u7406\u60f3\u3092\u7528\u3044\u3066\u5f97\u3089\u308c\u308b\u3067\u3042\u308d\u3046\u52b9\u679c\u306e\u6e2c\u5b9a\u5024\u3068\u306e\u9593\u306e\u5dee\u306e\u5168\u90e8\u307e\u305f\u306f\u4e00\u90e8\u3092\u8aac\u660e\u3059\u308b\u304b\u3001\u307e\u305f\u306f\u4f5c\u308a\u51fa\u3059\u56e0\u5b50\uff08\u66b4\u9732\u3001\u4ecb\u5165\u3001\u6cbb\u7642\u306a\u3069\uff09\u3067\u3042\u308b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u75ab\u5b66Epidemiology\u3068\u81e8\u5e8a\u75ab\u5b66Clinical Epidemiology\u306f\u540c\u3058\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u524d\u8005\u306e\u65b9\u304c\u6b74\u53f2\u304c\u9577\u304f\u3001\u975e\u5e38\u306b\u5965\u304c\u6df1\u3044\u9818\u57df\u3067\u3059\u3002Evidence-Based Medicine (EBM)\u306b\u8208\u5473\u3092\u6301\u3063\u3066 &hellip; <a href=\"https:\/\/info.zanet.biz\/?p=968\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;\u4ea4\u7d61\u56e0\u5b50Confounders&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[],"class_list":["post-968","post","type-post","status-publish","format-standard","hentry","category-essay","category-sr"],"_links":{"self":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/968","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=968"}],"version-history":[{"count":3,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/968\/revisions"}],"predecessor-version":[{"id":972,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/968\/revisions\/972"}],"wp:attachment":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=968"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=968"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}