{"id":801,"date":"2020-01-31T22:53:00","date_gmt":"2020-01-31T13:53:00","guid":{"rendered":"https:\/\/info.zanet.biz\/?p=801"},"modified":"2020-02-01T01:51:06","modified_gmt":"2020-01-31T16:51:06","slug":"%e5%89%8d%e7%ab%8b%e8%85%ba%e7%99%8c%e3%81%aepsa%e3%81%ab%e3%82%88%e3%82%8b%e3%82%b9%e3%82%af%e3%83%aa%e3%83%bc%e3%83%8b%e3%83%b3%e3%82%b0","status":"publish","type":"post","link":"https:\/\/info.zanet.biz\/?p=801","title":{"rendered":"\u524d\u7acb\u817a\u764c\u306ePSA\u306b\u3088\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0"},"content":{"rendered":"\n<p>US Preventive Services Task Force (USPSTF)\u306f55\u6b73\u304b\u308969\u6b73\u307e\u3067\u306e\u7537\u6027\u306e\u524d\u7acb\u817a\u764c\u306ePSA (Prostate Specific Antigen)\u306e\u5b9a\u671f\u7684\u691c\u67fb\u306b\u3088\u308b<a href=\"https:\/\/www.uspreventiveservicestaskforce.org\/Page\/Document\/RecommendationStatementFinal\/prostate-cancer-screening1\">\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/a>\u306f\u500b\u5225\u306b\u9069\u7528\u3059\u3079\u304d\u3067\u3042\u308b\u3068\u3001\u305d\u306e\u63a8\u5968Grade\u306fC\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001\u524d\u7acb\u817a\u764c\u306e\u767a\u75c7\u306f\u6570\u591a\u304f\u306e\u907a\u4f1d\u5b50\u304c\u304b\u304b\u308f\u3063\u3066\u3044\u308bpolygenic\u306a\u6a5f\u5e8f\u306b\u3088\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u3059(1)\u3002Schumacher FR\u304c\u7b46\u982d\u8457\u8005\u3067\u3059\u304c\u3001\u3053\u306e\u7814\u7a76\u306b\u306f\u4e16\u754c\u4e2d\u306e139\u65bd\u8a2d\u304c\u53c2\u52a0\u3057\u3066\u304a\u308a\u3001\u591a\u6570\u306e\u8457\u8005\u306b\u3088\u308b\u3001\u56fd\u969b\u898f\u6a21\u306e\u4e00\u5927\u7814\u7a76\u306e\u8ad6\u6587\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3066\u30012019\u5e74Callender T\u3089\u306f\u5e74\u9f62\u3068polygenic profile\u306b\u57fa\u3065\u304d\u3001\u524d\u7acb\u817a\u764c\u306e\u30ea\u30b9\u30af\u3092\u63a8\u5b9a\u3057\u3001\u30ea\u30b9\u30af\u306e\u7a0b\u5ea6\u306b\u3088\u3063\u3066PSA\u306b\u3088\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u6709\u52b9\u6027\u3092\u89e3\u6790\u3057\u305f\u8ad6\u6587\u3092\u767a\u8868\u3057\u307e\u3057\u305f(2)\u300210\u5e74\u306e\u524d\u7acb\u817a\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c4\uff05\u306b\u306a\u308b\u3068\u3001\u4e0a\u8a18\u306e\u5e74\u9f62\u30674\u5e74\u3054\u3068\u306ePSA\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u6bd4\u3079\u3001\u904e\u5270\u8a3a\u65ad\u304c3\u5206\u306e1\u6e1b\u5c11\u3059\u308b\u304c\u3001\u6b7b\u4ea1\u306f6.3\uff05\u5c11\u306a\u3044\u3060\u3051\u3068\u3044\u3046\u7d50\u679c\u3067\u3057\u305f\u3002\u8cbb\u7528\u5bfe\u52b9\u679c\u3082\u3059\u3050\u308c\u3066\u304a\u308a\u3001\u4e00\u5f8b\u306bPSA\u6e2c\u5b9a\u306b\u3088\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3046\u3088\u308a\u3001\u30ea\u30b9\u30af\u3067\u5c64\u5225\u5316\u3057\u3066\u4e00\u5b9a\u306e\u95be\u5024\u4ee5\u4e0a\u306e\u5834\u5408\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u5b9f\u65bd\u3079\u304d\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u7d50\u8ad6\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30dd\u30d4\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u5168\u4f53\u3067\u89e3\u6790\u3059\u308b\u3068\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u30cf\u30fc\u30e0\uff08\u76ca\u304c\u5bb3\uff09\u3092\u4e0a\u56de\u308b\u3068\u3044\u3048\u306a\u3044\u5834\u5408\u3067\u3082\u3001\u4e00\u5b9a\u4ee5\u4e0a\u306e\u30ea\u30b9\u30af\u306e\u4e9c\u7fa4\uff08Subpopulation)\u3067\u306f\u6b63\u5473\u306e\u76ca\u304c\u5f97\u3089\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u4ed6\u306e\u72b6\u6cc1\u3067\u3082\u3042\u308a\u3048\u307e\u3059\u3002Precision Medicine\u306e\u65b9\u5411\u3078\u9032\u3080\u3053\u3068\u304c\u5fc5\u8981\u306a\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3059\u3002\u305d\u308c\u3092\u3069\u306e\u3088\u3046\u306a\u65b9\u6cd5\u3067\u8a3c\u660e\u3059\u308b\u306e\u304b\u3001\u3069\u306e\u3088\u3046\u306a\u7814\u7a76\u624b\u6cd5\u304c\u5fc5\u8981\u306a\u306e\u304b\u3001\u8003\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002Callender T\u3089\u306e\u7814\u7a76\u306f\u3001&#8221;Benefit-harm and cost-effectiveness modelling study&#8221;\u3068\u30bf\u30a4\u30c8\u30eb\u306b\u3082\u66f8\u304b\u308c\u3066\u3044\u308b\u901a\u308a\u3001\u5b9f\u969b\u306b\u65b0\u305f\u306a\u30c7\u30fc\u30bf\u3092\u53ce\u96c6\u3057\u305f\u8a33\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u610f\u601d\u6c7a\u5b9a\u306b\u6709\u7528\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6587\u732e\uff1a<br>(1) Schumacher FR, Al Olama AA, Berndt SI, et al: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nat Genet 2018;50:928-936. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=29892016[uid]\">29892016<\/a><br>(2) Callender T, Emberton M, Morris S, Eeles R, Kote-Jarai Z, Pharoah PDP, Pashayan N: Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study. PLoS Med 2019;16:e1002998. 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