{"id":796,"date":"2020-01-31T20:54:14","date_gmt":"2020-01-31T11:54:14","guid":{"rendered":"https:\/\/info.zanet.biz\/?p=796"},"modified":"2020-01-31T22:23:58","modified_gmt":"2020-01-31T13:23:58","slug":"bias-adjustment-thresholds","status":"publish","type":"post","link":"https:\/\/info.zanet.biz\/?p=796","title":{"rendered":"Bias adjustment thresholds"},"content":{"rendered":"\n<p>2019\u5e74\u306bAnnals of Internal Medicine\u306bPhillippo DM\u3089\u304b\u3089\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3088\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u78ba\u5b9f\u6027\u304b\u3089\u3055\u3089\u306b\u81e8\u5e8a\u6c7a\u65ad\u3078\u306e\u30d0\u30a4\u30a2\u30b9\u306e\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u65b0\u3057\u3044\u624b\u6cd5\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f(1)\u3002GRADE (Grading of  Recommendations Assessment, Development and Evaluation)\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u78ba\u5b9f\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5(2, 3)\u3068\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u304c\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Bias adjustment thresholds\u3092\u7528\u3044\u308b\u65b9\u6cd5\u3067\u3059\u3002GRADE\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u306f\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u3001\u975e\u76f4\u63a5\u6027\u3001\u4e0d\u7cbe\u78ba\u6027\u3001\u975e\u4e00\u8cab\u6027\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u3092\u8a55\u4fa1\u3057\u3001\u8907\u6570\u306e\u7814\u7a76\u3092\u307e\u3068\u3081\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u78ba\u5b9f\u6027\u306e\u8a55\u4fa1\u3092\u884c\u3044\u307e\u3059\u304c\u3001\u76f4\u63a5\u3001\u81e8\u5e8a\u6c7a\u65ad\u3042\u308b\u3044\u306f\u63a8\u5968\u3078\u306e\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002Phillippo DM\u3089\u306e\u65b9\u6cd5\u3067\u306f\u3001\u81e8\u5e8a\u6c7a\u65ad\u3092\u9006\u8ee2\u3055\u305b\u308b\u30d0\u30a4\u30a2\u30b9\u306e\u95be\u5024\u3092\u8a55\u4fa1\u3057\u3001\u5b9f\u969b\u306e\u7814\u7a76\u306e\u7d50\u679c\u306b\u5bfe\u3057\u3066\u305d\u308c\u4ee5\u4e0a\u306e\u30d0\u30a4\u30a2\u30b9\u306e\u5f71\u97ff\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3057\u3066\u3001\u81e8\u5e8a\u6c7a\u65ad\u304c\u9006\u8ee2\u3057\u3046\u308b\u304b\u3069\u3046\u304b\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306bGRADE\u306e\u65b9\u6cd5\u3092\u7528\u3044\u305f\u5834\u5408\u3068\u7570\u306a\u308b\u7d50\u8ad6\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Phillippo DM\u3089\u306e\u8ad6\u6587\u306f\u3001\u3082\u3068\u3082\u30682016\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u540c\u3058\u30b0\u30eb\u30fc\u30d7\u306eCaldwell DM\u3089\u306e\u8ad6\u6587(4)\u304c\u3082\u3068\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u30012018\u5e74\u306b\u306fJournal of Royal Statistical Society\u306eSeries A\u306bPhillippo DM, Dias S, Ades AE\u3089\u306e\u8ad6\u6587(5)\u3068\u3057\u3066\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002Journal of Royal Statistical Society\u306b\u306f2009\u5e74\u306bTurner RM\u3089\u306e\u30d0\u30a4\u30a2\u30b9\u306e\u5b9a\u91cf\u7684\u30e2\u30c7\u30eb\u5316\u306e\u8ad6\u6587(6)\u304c\u767a\u8868\u3055\u308c\u3066\u304a\u308a\u3001\u5f53\u7136\u306e\u3053\u3068\u306a\u304c\u3089\u5f15\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3060\u3051\u3067\u306a\u304f\u901a\u5e38\u306e\u30da\u30a2\u6bd4\u8f03\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3064\u3044\u3066\u3082\u540c\u3058\u624b\u6cd5\u304c\u9069\u7528\u53ef\u80fd\u3067\u3059\u3002\u975e\u5e38\u306b\u91cd\u8981\u306a\u8ad6\u6587\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6587\u732e\uff1a<br>(1) Phillippo DM, Dias S, Welton NJ, Caldwell DM, Taske N, Ades AE: Threshold Analysis as an Alternative to GRADE for Assessing Confidence in Guideline Recommendations Based on Network Meta-analyses. Ann Intern Med 2019;170:538-546. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=30909295[uid]\">30909295<\/a><br>(2) Guyatt G, Oxman AD, Sultan S, Brozek J, Glasziou P, Alonso-Coello P, Atkins D, Kunz R, Montori V, Jaeschke R, Rind D, Dahm P, Akl EA, Meerpohl J, Vist G, Berliner E, Norris S, Falck-Ytter Y, Sch\u00fcnemann HJ: GRADE guidelines: 11. Making an overall rating of confidence in effect estimates for a single outcome and for all outcomes. J Clin Epidemiol 2013;66:151-7. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=22542023[uid]\">22542023<\/a><br>(3) Balshem H, Helfand M, Sch\u00fcnemann HJ, Oxman AD, Kunz R, Brozek J, Vist GE, Falck-Ytter Y, Meerpohl J, Norris S, Guyatt GH: GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol 2011;64:401-6. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=21208779[uid]\">21208779<\/a><br>(4) Caldwell DM, Ades AE, Dias S, Watkins S, Li T, Taske N, Naidoo B, Welton NJ: A threshold analysis assessed the credibility of conclusions from network meta-analysis. J Clin Epidemiol 2016;80:68-76. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=27430731[uid]\">27430731<\/a><br>(5) Phillippo DM, Dias S, Ades AE, Didelez V, Welton NJ: Sensitivity of treatment recommendations to bias in network meta-analysis. J R Stat Soc Ser A Stat Soc 2018;181:843-867. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=30449954[uid]\">30449954<\/a><br>(6) Turner RM, Spiegelhalter DJ, Smith GC, Thompson SG: Bias modelling in evidence synthesis. J R Stat Soc Ser A Stat Soc 2009;172:21-47. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=19381328[uid]\">19381328<\/a><\/p>\n\n\n\n<p>\u4e0b\u306e\u56f3\u3092\u898b\u3066\u3001\u30d0\u30a4\u30a2\u30b9\u306e\u52b9\u679c\u306b\u3064\u3044\u3066\u3061\u3087\u3063\u3068\u8003\u3048\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/01\/bias_effect-1024x554.png\" alt=\"\" class=\"wp-image-799\" width=\"512\" height=\"277\" srcset=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/01\/bias_effect-1024x554.png 1024w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/01\/bias_effect-300x162.png 300w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/01\/bias_effect-768x416.png 768w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/01\/bias_effect-1200x650.png 1200w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2020\/01\/bias_effect.png 1452w\" sizes=\"auto, (max-width: 512px) 85vw, 512px\" \/><figcaption>Bias effects. RR: Risk Ratio; Log (Natural logarithm) of RR normally distribute and are additive, while on ratio scale RR is multiplicative.<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>2019\u5e74\u306bAnnals of Internal Medicine\u306bPhillippo DM\u3089\u304b\u3089\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3088\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u78ba\u5b9f\u6027\u304b\u3089\u3055\u3089\u306b\u81e8\u5e8a\u6c7a\u65ad\u3078\u306e\u30d0\u30a4\u30a2\u30b9\u306e\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u65b0\u3057\u3044\u624b\u6cd5\u304c\u5831 &hellip; <a href=\"https:\/\/info.zanet.biz\/?p=796\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Bias adjustment thresholds&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,5,3,32,2],"tags":[],"class_list":["post-796","post","type-post","status-publish","format-standard","hentry","category-benefit-harm-assessment","category-cpg","category-mdm","category-statistics","category-sr"],"_links":{"self":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=796"}],"version-history":[{"count":2,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/796\/revisions"}],"predecessor-version":[{"id":800,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/796\/revisions\/800"}],"wp:attachment":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}