{"id":1818,"date":"2025-06-23T20:38:04","date_gmt":"2025-06-23T11:38:04","guid":{"rendered":"https:\/\/info.zanet.biz\/?p=1818"},"modified":"2025-06-23T20:38:06","modified_gmt":"2025-06-23T11:38:06","slug":"meta%e3%82%92%e4%bd%bf%e3%81%a3%e3%81%9f%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9","status":"publish","type":"post","link":"https:\/\/info.zanet.biz\/?p=1818","title":{"rendered":"meta\u3092\u4f7f\u3063\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9"},"content":{"rendered":"\n<p>R\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u7528\u306e<a href=\"https:\/\/cran.r-project.org\/web\/packages\/meta\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u30d1\u30c3\u30b1\u30fc\u30b8meta<\/a>\u306b\u3064\u3044\u3066\u3001<a href=\"\/index.php?p=1656\" target=\"_blank\" rel=\"noreferrer noopener\">\u4ee5\u524d\u306e\u6295\u7a3f<\/a>\u3067\u7d39\u4ecb\u3057\u307e\u3057\u305f\u300cCopilot\u306b\u805e\u304d\u306a\u304c\u3089\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u5b9f\u884c\uff1ameta\u30d1\u30c3\u30b1\u30fc\u30b8\u3092\u4f7f\u3063\u3066\u300d<\/p>\n\n\n\n<p>\u4eca\u56de\u306f\u3001Excel\u3067\u5404\u7814\u7a76\u304b\u3089\u7814\u7a76ID\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u5fc5\u8981\u306a\u30c7\u30fc\u30bf\u3092\u62bd\u51fa\u3057\u305f\u8868\u3092\u4f5c\u6210\u3057\u3001\u305d\u306e\u30c7\u30fc\u30bf\u304b\u3089R\u3067meta\u3092\u52d5\u304b\u3057\u3066\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u5b9f\u884c\u3059\u308bR\u7528\u306e\u30b9\u30af\u30ea\u30d7\u30c8\u3092\u4f5c\u6210\u3057\u3066\u307f\u307e\u3057\u305f\u3002Inverse variance method\u306b\u3088\u308b\u30e9\u30f3\u30c0\u30e0\u52b9\u679c\u30e2\u30c7\u30eb\u3067\u3001\u7814\u7a76\u9593\u306e\u5206\u6563\u306fREML\uff08Restricted Maximum Likelihood)\u6cd5\u3092\u7528\u3044\u3066\u3044\u307e\u3059\u3002\u5bfe\u5fdc\u3059\u308b\u52b9\u679c\u6307\u6a19\u306e\u30bf\u30a4\u30d7\u306fRR, RD, OR, HR, MD, SMD\u3067\u3059\u3002<\/p>\n\n\n\n<p>Excel\u3067\u4f5c\u6210\u3059\u308b\u8868\u306f\u3001\u7814\u7a76ID\u3001\u4eba\u6570\u3001\u5e73\u5747\u5024\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\u306e\u81ea\u7136\u5bfe\u6570\u306a\u3069\u306e\u30c7\u30fc\u30bf\u3068\u3001label\u306e\u30ab\u30e9\u30e0\u306b\u3001\u7814\u7a76ID\u306e\u30ab\u30e9\u30e0\u306e\u30e9\u30d9\u30eb\u3001\u5bfe\u7167\u3001\u4ecb\u5165\u306e\u540d\u79f0\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u3001\u52b9\u679c\u6307\u6a19\u306e\u30bf\u30a4\u30d7\u3068\u7701\u7565\u5f62\u3001\u30d5\u30a9\u30ec\u30b9\u30c8\u30d7\u30ed\u30c3\u30c8\u306e\u30ec\u30a4\u30a2\u30a6\u30c8\uff08meta, RevMan5, JAMA\u306e\u3044\u305a\u308c\u304b\uff09\u3001Prediction Interval\u3092\u542b\u3081\u308b\u304b\u3069\u3046\u304b\uff08No Prediction Interval\u307e\u305f\u306fPrediction Interval\uff09\u3092\u5165\u529b\u3057\u307e\u3059\u3002\u30d5\u30a9\u30ec\u30b9\u30c8\u30d7\u30ed\u30c3\u30c8\u306f\u3053\u308c\u3089\u306e\u30e9\u30d9\u30eb\u3092\u8868\u793a\u3057\u307e\u3059\u3002\u30b5\u30f3\u30d7\u30eb\u306eExcel\u30d5\u30a1\u30a4\u30eb\u306f<a href=\"https:\/\/stat.zanet.biz\/useRs\/exc\/meta-analysis-sample-data.xlsx\" target=\"_blank\" rel=\"noreferrer noopener\">\u3053\u3061\u3089\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a>\u3067\u304d\u307e\u3059\u306e\u3067\u3001\u53f3\u30af\u30ea\u30c3\u30af\u3057\u3066\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u3001\u30c7\u30fc\u30bf\u3092\u66f8\u304d\u63db\u3048\u3066\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>R\u3092\u8d77\u52d5\u3057\u3066\u304a\u3044\u3066\u3001\u65b0\u898f\u30a8\u30c7\u30a3\u30bf\u306e\u30d5\u30a3\u30fc\u30eb\u30c9\u306b\u4ee5\u4e0b\u306e\u30b9\u30af\u30ea\u30d7\u30c8\u3092\u8cbc\u308a\u4ed8\u3051\u3001\u30ab\u30fc\u30bd\u30eb\u3092\u305d\u306e\u884c\u306b\u7f6e\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code>exdat = read.table(\"clipboard\", sep = \"\\t\", header = TRUE);source(\"https:\/\/stat.zanet.biz\/useRs\/scripts\/with-meta-all.R\")<\/code><\/pre>\n\n\n\n<p>Excel\u306e\u30b7\u30fc\u30c8\u3092\u958b\u304d\u3001\u30c7\u30fc\u30bf\u3092\u542b\u3080\u7bc4\u56f2\u3092\u9078\u629e\u3057\u3066\u3001\u30b3\u30d4\u30fc\uff08Ctr+C)\u64cd\u4f5c\u3092\u5b9f\u884c\u3057\u3001R\u306b\u3082\u3069\u308a\u3001\u4e0a\u8a18\u306e\u4e00\u884c\u3092\u5b9f\u884c\u3057\u307e\u3059\u3002\u5fc5\u8981\u306a\u30b9\u30af\u30ea\u30d7\u30c8\u3092\u30a6\u30a8\u30d6\u30b5\u30fc\u30d0\u30fc\u304b\u3089\u8aad\u307f\u8fbc\u307f\u3001\u5b9f\u884c\u3057\u3066\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u7d50\u679c\u304c\u30b3\u30f3\u30bd\u30fc\u30eb\u306b\u51fa\u529b\u3055\u308c\u3001Forest plot\u3068Funnel plot\u304c\u4f5c\u6210\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"980\" height=\"459\" src=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-46.png\" alt=\"\" class=\"wp-image-1819\" srcset=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-46.png 980w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-46-300x141.png 300w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-46-768x360.png 768w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><figcaption class=\"wp-element-caption\">Forest plot \uff1a meta\u5f62\u5f0f\u3067Prediction Interval\u3092\u542b\u3081\u305f\u5834\u5408\u3002\u5de6\u4e0b\u306b\u8868\u793a\u3055\u308c\u308bP\u5024\u306fQ\u7d71\u8a08\u5024\u306b\u5bfe\u3059\u308b\u3082\u306e\u3067\u3001\u7d71\u5408\u5024\u306b\u5bfe\u3059\u308bZ\u5024\u3001P\u5024\u306f\u30b3\u30f3\u30bd\u30fc\u30eb\u306b\u51fa\u529b\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u4f8b\u3067\u306f\u3001Z=-3.97\u3001P&lt;0.0001\u3067\u3057\u305f\u3002<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"429\" height=\"445\" src=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-47.png\" alt=\"\" class=\"wp-image-1820\" style=\"width:358px;height:auto\" srcset=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-47.png 429w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-47-289x300.png 289w\" sizes=\"auto, (max-width: 429px) 85vw, 429px\" \/><figcaption class=\"wp-element-caption\">Funnel plot\u3002Begg &amp; Mazumdar\u306e\u691c\u5b9a\u306e\u7d50\u679c\u3068Egger\u306e\u691c\u5b9a\u306e\u7d50\u679c\u306f\u30b3\u30f3\u30bd\u30fc\u30eb\u306b\u51fa\u529b\u3055\u308c\u3001\u3053\u306e\u4f8b\u3067\u306fP=0.9028, P=0.1887\u3067\u3057\u305f\u3002<\/figcaption><\/figure>\n\n\n\n<p>\u3055\u3066\u3001Minds\u306e\u8a55\u4fa1\u30b7\u30fc\u30c8\u3067\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u5fc5\u8981\u306a\u30c7\u30fc\u30bf\u3092\u5165\u529b\u3057\u3066\u3042\u308b\u5834\u5408\u3001\u5de6\u4e0a\u30bb\u30ebA3\uff08\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff09\u304b\u3089\u3001\u53f3\u4e0b\u306e\u65b9\u306e\u52b9\u679c\u6307\u6a19\uff08\u7a2e\u985e\uff09\u306e\u30ab\u30e9\u30e0\u3067\u3001\u30c7\u30fc\u30bf\u3092\u542b\u3080\u884c\u307e\u3067\u306e\u7bc4\u56f2\u3092\u9078\u629e\u3057\u3066\u3001\u30b3\u30d4\u30fc\uff08Ctr+C)\u64cd\u4f5c\u3092\u5b9f\u884c\u3057\u3001R\u306b\u3082\u3069\u308a\u3001\u4ee5\u4e0b\u306e\u30b3\u30fc\u30c9\u306eexdato=read.delim(&#8220;clipboard&#8221;,sep=&#8221;\\t&#8221;,header=TRUE);\u3092\u5b9f\u884c\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30af\u30ea\u30c3\u30d7\u30dc\u30fc\u30c9\u7d4c\u7531\u3067\u3001\u30c7\u30fc\u30bf\u304c\u5909\u6570exdato\u306b\u683c\u7d0d\u3055\u308c\u307e\u3059\u3002\u305d\u3057\u3066\u3001###Start\u306e\u884c\u304b\u3089\u3001#####End\u306e\u884c\u307e\u3067\u3092\u9078\u629e\u3057\uff08\u53cd\u8ee2\u3057\u305f\u72b6\u614b\u3067\uff09\u3001\u5b9f\u884c\u3057\u307e\u3059\uff08Windows\u306e\u5834\u5408\u306f\u5b9f\u884c\u30dc\u30bf\u30f3\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u304b\u3001Ctr+R\u3001Mac\u306fcommand+enter\u3092\u62bc\u3057\u307e\u3059\uff09\u3002\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u304c\u5b9f\u884c\u3055\u308c\u7d50\u679c\u304c\u30b3\u30f3\u30bd\u30fc\u30eb\u306b\u51fa\u529b\u3055\u308c\u3001Forest plot\u3068Funnel plot\u304c\u4f5c\u6210\u3055\u308c\u307e\u3059\u3002\u306a\u304a\u3001\u30af\u30ea\u30c3\u30d7\u30dc\u30fc\u30c9\u304b\u3089\u30c7\u30fc\u30bf\u3092\u8aad\u307f\u8fbc\u3080\u64cd\u4f5c\u3068\u3001#####Start\u4ee5\u4e0b\u306e\u30b9\u30af\u30ea\u30d7\u30c8\u306f\u5206\u3051\u3066\u5b9f\u884c\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code>#Meta-analysis with meta from Minds sheet.\n#Select the range A3 \uff5e down the effect measure column and run these scripts in R.\n#Read data via clipboard from Minds sheet.\nexdato=read.delim(\"clipboard\",sep=\"\\t\",header=TRUE);\n\n#####Start\n#Reformat the data frame.\nsource(\"https:\/\/stat.zanet.biz\/useRs\/scripts\/to_forest_metafor.R\");\n\n#Add cells to the label clumn for layout and Prediction Interval.\nif(nrow(exdat)==6){\nnew_row &lt;- exdat&#91;1, ]\nnew_row&#91;,] &lt;- NA\nexdat &lt;- rbind(exdat, new_row)\n\n}\nif(nrow(exdat)==7){\nnew_row &lt;- exdat&#91;1, ]\nnew_row&#91;,] &lt;- NA\nexdat &lt;- rbind(exdat, new_row)\n}\n\n#Choose a forest plot layout: remove # of the format you want to use.\nexdat$label&#91;7] = \"meta\"\n#exdat$label&#91;7] = \"RevMan5\"\n#exdat$label&#91;7] = \"JAMA\"\n\n#Choose \"No Prediction Interval\" or \"Prediction Interval\": remove # of the what you want.\nexdat$label&#91;8] = \"No Prediction Interval\"\n#exdat$label&#91;8] = \"Prediction Interval\"\n\n#Do meta-analysis with meta to create forest plot and funnel plot.\nsource(\"https:\/\/stat.zanet.biz\/useRs\/scripts\/with-meta-all.R\")\n#####End<\/code><\/pre>\n\n\n\n<p>\u3053\u306e\u30b9\u30af\u30ea\u30d7\u30c8\u3067\u306fForest plot\u306e\u5f62\u5f0f\u306f3\u7a2e\u985e\u304b\u3089\u9078\u629e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u3001#\u306e\u3064\u3044\u3066\u3044\u306a\u3044\u884c\u306e\u5f62\u5f0f\u306b\u306a\u308a\u307e\u3059\u3002\u30c7\u30d5\u30a9\u30eb\u30c8\u3067\u306fmeta\u306e\u5f62\u5f0f\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u4f8b\u3048\u3070\u3082\u3057RevMan5\u306e\u5f62\u5f0f\u306b\u3057\u305f\u3051\u308c\u3070\u3001#exdat$label[7] = &#8220;meta&#8221;\u3068#\u3092\u884c\u982d\u306b\u4ed8\u3051\u3001exdat$label[7] = &#8220;RevMan5&#8243;\u3068\u3053\u3061\u3089\u306e#\u306f\u5916\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>Prediction Interval\u3092\u542b\u3081\u308b\u304b\u3069\u3046\u304b\u3082\u540c\u3058\u3088\u3046\u306b\u3001\u884c\u982d\u306b#\u304c\u4ed8\u3044\u3066\u3044\u306a\u3044\u65b9\u304c\u5b9f\u884c\u3055\u308c\u307e\u3059\u3002\u30c7\u30d5\u30a9\u30eb\u30c8\u3067\u306fNo Prediction Interval\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3082\u3057Prediction Interval\u3092\u542b\u3081\u305f\u3044\u306e\u3067\u3042\u308c\u3070\u3001#exdat$label[8] = &#8220;No Prediction Interval&#8221;\u3068\u884c\u982d\u306b#\u3092\u4ed8\u3051\u3001exdat$label[8] = &#8220;Prediction Interval&#8221;\u3068\u3053\u3061\u3089\u306e#\u306f\u5916\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"983\" height=\"452\" src=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-48.png\" alt=\"\" class=\"wp-image-1821\" srcset=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-48.png 983w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-48-300x138.png 300w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-48-768x353.png 768w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><figcaption class=\"wp-element-caption\">RevMan5\u306e\u5f62\u5f0f\u306eForest plot\u3002<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"672\" height=\"402\" src=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-49.png\" alt=\"\" class=\"wp-image-1822\" style=\"width:432px;height:auto\" srcset=\"https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-49.png 672w, https:\/\/info.zanet.biz\/wp\/wp-content\/uploads\/2025\/06\/image-49-300x179.png 300w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><figcaption class=\"wp-element-caption\">JAMA\u306e\u5f62\u5f0f\u306eForest plot\u3002<\/figcaption><\/figure>\n\n\n\n<p>\u51fa\u529b\u3055\u308c\u305fForest plot\u306f\u5de6\u53f3\u304c\u77ed\u304f\u3001\u4e0a\u4e0b\u306e\u4f59\u767d\u304c\u5927\u304d\u3081\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u3001R\u4e0a\u3067\u5927\u304d\u3055\u3092\u5909\u66f4\u3057\u3066\u304b\u3089\u3001\u53f3\u30af\u30ea\u30c3\u30af\u3057\u3066\u30b3\u30d4\u30fc\u3057\u3066PPT\u3084Word\u306a\u3069\u306b\u8cbc\u308a\u4ed8\u3051\u305f\u308a\u3001\u30d5\u30a1\u30a4\u30eb\u3068\u3057\u3066\u4fdd\u5b58\u3057\u307e\u3059\u3002Forest plot\u3082Funnel plot\u3082\u3001\u30d7\u30ed\u30c3\u30c8\u3092\u9078\u629e\u3057\u3066\u3001\u30d5\u30a1\u30a4\u30eb\u30e1\u30cb\u30e5\u30fc\u304b\u3089\u3082\u5225\u540d\u3067\u4fdd\u5b58\u304b\u3089PNG\u3001JPEG\u3001PDF\u3001TIFF\u3001Postscript\u4ed6\u306e\u5f62\u5f0f\u3092\u9078\u3093\u3067\u3001\u4fdd\u5b58\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u306a\u304a\u3001Funnel 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