{"id":1538,"date":"2024-12-31T22:14:14","date_gmt":"2024-12-31T13:14:14","guid":{"rendered":"https:\/\/info.zanet.biz\/?p=1538"},"modified":"2025-01-17T10:57:50","modified_gmt":"2025-01-17T01:57:50","slug":"%e6%ad%a3%e5%91%b3%e3%81%ae%e7%9b%8a%e3%81%8c%e5%8f%8d%e8%bb%a2%e3%81%97%e3%81%aa%e3%81%84%e9%96%be%e5%80%a4%ef%bc%9a%e5%8a%b9%e6%9e%9c%e6%8e%a8%e5%ae%9a%e5%80%a4%e3%81%a8%e3%82%a2%e3%82%a6%e3%83%88","status":"publish","type":"post","link":"https:\/\/info.zanet.biz\/?p=1538","title":{"rendered":"\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u95be\u5024\uff1a\u52b9\u679c\u63a8\u5b9a\u5024\u3068\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6"},"content":{"rendered":"\n

T\u500b\u306e\u4ecb\u5165\u304c\u3042\u308b\u3068\u3057\u3001\u4ecb\u5165i\u306e\u52b9\u679c\u3092\u4ecb\u5165j\u3059\u306a\u308f\u3061\u5bfe\u7167\u3068\u6bd4\u8f03\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067K\u500b\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c\u30ea\u30b9\u30af\u5dee\u3067\u5f97\u3089\u308c\u305f\u3068\u3059\u308b\u3002\u305d\u3053\u3067\u3001\u30da\u30a2\u3067\u6b63\u5473\u306e\u76ca\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3059\u308b\u3002\uff08i, j, T, K, L\u306f\u6574\u6570\uff09\u3002<\/p>\n\n\n\n

\"\"
\u56f31. \u6b63\u5473\u306e\u76ca\u306e\u53cd\u8ee2\u95be\u5024\uff1a\u52b9\u679c\u63a8\u5b9a\u5024\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u3002<\/figcaption><\/figure>\n\n\n\n

\u30ea\u30b9\u30af\u5deeEij\u306f\u4ecb\u5165i\u3001\u3059\u306a\u308f\u3061\u4ecb\u5165\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\uff08\u30a4\u30d9\u30f3\u30c8\u7387\uff09\u304b\u3089\u4ecb\u5165j\u3001\u3059\u306a\u308f\u3061\u5bfe\u7167\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\uff08\u30a4\u30d9\u30f3\u30c8\u7387\uff09\u3092\u5f15\u304d\u7b97\u3057\u305f\u5024\u3068\u3059\u308b\u3002\u5f93\u3063\u3066\u3001\u3082\u3057\u3001\u6709\u5bb3\u306a\u4e8b\u8c61\u304c\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5185\u5bb9\u3067\u3001Eij\u304c\u30d7\u30e9\u30b9\u306e\u5024\u3067\u3042\u308c\u3070\u3001\u52b9\u679c\u306f\u5bb3\u3067\u3042\u308a\u3001\u9006\u306bEij\u304c\u30de\u30a4\u30ca\u30b9\u306e\u5024\u3067\u3042\u308c\u3070\u3001\u76ca\u3067\u3042\u308b\u3002\u3082\u3057\u3001\u6709\u76ca\u306a\u4e8b\u8c61\u304c\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5185\u5bb9\u306e\u5834\u5408\u306f\u3001\u305d\u306e\u9006\u3067\u3001Eij\u304c\u30d7\u30e9\u30b9\u306e\u5024\u3067\u3042\u308c\u3070\u3001\u76ca\u3067\u3042\u308a\u3001\u30de\u30a4\u30ca\u30b9\u306e\u5024\u3067\u3042\u308c\u3070\u5bb3\u3068\u306a\u308b\u3002\u305f\u3060\u3057\u3001\u30ea\u30b9\u30af\u5dee\u306f\u4ecb\u5165\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\uff0d\u5bfe\u8c61\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u3068\u3057\u3066\u8a08\u7b97\u3059\u308b\u3053\u3068\u3092\u30eb\u30fc\u30eb\u3068\u3059\u308b\u3002<\/p>\n\n\n\n

\u52b9\u679c\u63a8\u5b9a\u5024\u3068\u52b9\u679c\u306e\u671b\u307e\u3057\u3055\u306e\u95a2\u4fc2\u3092\u3082\u3046\u4e00\u5ea6\u8003\u3048\u3066\u307f\u308b\u3068\u3001\u30ea\u30b9\u30af\u5deeEij\u306e\u5024\u304c\u5927\u304d\u304f\u306a\u308b\u65b9\u304c\u671b\u307e\u3057\u3044\u52b9\u679c\u306e\u5834\u5408\u306f\u3001\u6709\u76ca\u4e8b\u8c61\u304c\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5185\u5bb9\u3067\u3042\u308a\u3001\u9006\u306bEij\u304c\u5c0f\u3055\u3044\u65b9\u304c\u671b\u307e\u3057\u3044\u52b9\u679c\u306e\u5834\u5408\u306f\u3001\u6709\u5bb3\u4e8b\u8c61\u304c\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5185\u5bb9\u3067\u3042\u308b\u3002\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5185\u5bb9\u3068\u306f\u3001\u6e2c\u5b9a\u3055\u308c\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u4e8b\u8c61\u3068\u8a00\u3044\u63db\u3048\u3066\u3082\u3044\u3044\u3002\u6b63\u5473\u306e\u76ca\u304c\u30d7\u30e9\u30b9\u306b\u306a\u308c\u3070\u671b\u307e\u3057\u3044\u52b9\u679c\u304c\u671b\u307e\u3057\u304f\u306a\u3044\u52b9\u679c\u3092\u4e0a\u56de\u308a\u3001\u30de\u30a4\u30ca\u30b9\u306b\u306a\u308c\u3070\u671b\u307e\u3057\u304f\u306a\u3044\u52b9\u679c\u304c\u671b\u307e\u3057\u3044\u52b9\u679c\u3092\u4e0a\u56de\u308b\u3088\u3046\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u30a2\u30a6\u30c8\u30ab\u30e0k\u306b\u5bfe\u3059\u308b\u4fc2\u6570Fk\u3092\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5185\u5bb9\u304c\u6709\u76ca\u4e8b\u8c61\u306e\u5834\u5408\u306f1\u3001\u6709\u5bb3\u4e8b\u8c61\u306e\u5834\u5408\u306f-1\u306b\u8a2d\u5b9a\u3059\u308b\u3002<\/p>\n\n\n\n

\u30a2\u30a6\u30c8\u30ab\u30e0k\u306b\u5bfe\u3059\u308b\u91cd\u8981\u5ea6wk\u306f0\uff5e100\u306e\u5024\u3092\u8a2d\u5b9a\u3059\u308b\u3002\u6700\u3082\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u306b100\u3092\u8a2d\u5b9a\u3057\u3001\u305d\u306e\u4ed6\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3057\u3066\u306f\u76f8\u5bfe\u7684\u306a\u91cd\u8981\u5ea6\u30920\uff5e100\u306e\u6570\u5024\u3068\u3057\u3066\u8a2d\u5b9a\u3059\u308b\u3002\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u306f\u8a55\u4fa1\u8005\u304c\u305d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u7f6e\u304f\u4fa1\u5024\u306e\u5927\u304d\u3055\u3067\u3042\u308a\u3001\u8a55\u4fa1\u8005\u306e\u4fa1\u5024\u89b3\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u306e\u3067\u3001\u8a55\u4fa1\u8005\u3054\u3068\u306b\u7570\u306a\u308b\u4e3b\u89b3\u7684\u306a\u3082\u306e\u3067\u3042\u308b\u3002\u3082\u3057\u3001\u6700\u3082\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u304c100\u3067\u3042\u308b\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u304c20\u306b\u8a2d\u5b9a\u3059\u308b\u3068\u3001\u6700\u3082\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u305d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306e5\u500d\u91cd\u8981\u3068\u307f\u306a\u3057\u305f\u3053\u3068\u306b\u306a\u308b\u3002\u3082\u3057\u3001\u3069\u3061\u3089\u3082\u76ca\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u3067\u3042\u3063\u305f\u5834\u5408\u3001\u305d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u304c5\u4eba\u306b\u751f\u8d77\u3057\u305f\u4fa1\u5024\u306f\u6700\u3082\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u304c1\u4eba\u306b\u751f\u8d77\u3057\u305f\u4fa1\u5024\u3068\u540c\u3058\u3068\u8003\u3048\u305f\u3053\u3068\u306b\u306a\u308b\u3002\u306a\u304a\u3001Gail\/NCI\u306e\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u65b9\u6cd5\u3067\u306f\u91cd\u8981\u5ea6\u3092\u91cd\u8981\u3001\u4e2d\u7b49\u5ea6\u3001\u91cd\u8981\u3067\u306a\u3044\u306e\uff13\u6bb5\u968e\u3067\u30011, 0.5, 0\u3068\u3044\u3046\u5024\u3092\u8a2d\u5b9a\u3059\u308b\u3002\u3055\u3089\u306b\u3001\u611f\u5ea6\u5206\u6790\u3067\u306f\u4f8b\u3048\u3070\u30011,0.5,0.25\/1.0,1.0,1.0\/1.0,1.0,0\u306a\u3069\u7570\u306a\u308b\u5024\u3092\u8a2d\u5b9a\u3059\u308b\u3002<\/p>\n\n\n\n

\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u3092\u305d\u308c\u305e\u308c\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u306e\u7dcf\u548c\u3067\u5272\u308a\u7b97\u3057\u3066\u3001\u6a19\u6e96\u5316\u3057\u305f\u5024\u304cwsk\u3067\u3042\u308b\u3002\u6a19\u6e96\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u6570\u3092\u5897\u3084\u3057\u3066\u3082\u6b63\u5473\u306e\u76caNB\u306e\u5024\u306e\u7d76\u5bfe\u5024\u306f\u6700\u5927\u3067100\u3092\u8d85\u3048\u308b\u3053\u3068\u304c\u7121\u304f\u306a\u308b\u3002\u307e\u305f\u3001\u6700\u3082\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u306b\u5bfe\u3059\u308b\u6bd4\u306e\u5024\u3092\u7528\u3044\u308b\u3053\u3068\u3082\u3067\u304d\u308b\u3002\u305d\u306e\u5834\u5408\u306f\u3001\u6b63\u5473\u306e\u76ca\u306f\u6700\u3082\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u76f8\u5f53\u3059\u308b\u4fa1\u5024\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u304c\u751f\u8d77\u3057\u305f\u5bfe\u8c61\u8005\u306e\u5272\u5408\u307e\u305f\u306f\u4eba\u6570\u3092\u8868\u3059\u3053\u3068\u306b\u306a\u308b\u3002\u306a\u304a\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u3068\u4fa1\u5024\u306f\u540c\u3058\u610f\u5473\u3067\u3042\u308a\u3001\u6587\u8108\u306b\u3088\u308a\u4f7f\u3044\u5206\u3051\u3089\u308c\u308b\u3002<\/p>\n\n\n\n

\u6b63\u5473\u306e\u76caNB\uff08Net Benefit)\u306f\u56f31\u3067NB\u3068\u3057\u3066\u793a\u3059\u5f0f\u3067\u8a08\u7b97\u3055\u308c\u308b\u3002\u5404\u30a2\u30a6\u30c8\u30ab\u30e0\u3054\u3068\u306bFk\u3001\u6a19\u6e96\u5316\u3057\u305f\u91cd\u8981\u5ea6\u3001\u30ea\u30b9\u30af\u5dee\u3092\u639b\u3051\u7b97\u3057\u305f\u5024\u3092\u3059\u3079\u3066\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u3064\u3044\u3066\u52a0\u7b97\u3057\u3001\u7dcf\u548c\u3092\u6c42\u3081\u305f\u5024\u306b\u306a\u308b\u3002\u52b9\u679c\u306e\u5927\u304d\u3055\u3092\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u3067\u91cd\u307f\u3065\u3051\u3057\u305f\u7dcf\u548c\u3068\u8a00\u3048\u308b\u3002\u305f\u3060\u3057\u3001\u671b\u307e\u3057\u3044\u52b9\u679c\u306f\u30d7\u30e9\u30b9\u3001\u671b\u307e\u3057\u304f\u306a\u3044\u52b9\u679c\u306f\u30de\u30a4\u30ca\u30b9\u306b\u306a\u308b\u3088\u3046\u306b\u3057\u3066\u7dcf\u548c\u3092\u6c42\u3081\u308b\u3002\u306a\u304a\u3001\u6b63\u5473\u306e\u76canet benefit\u3068\u76ca\u3068\u5bb3\u306e\u30d0\u30e9\u30f3\u30b9 benefit-harm balance\u306f\u540c\u3058\u610f\u5473\u3067\u3042\u308b\u3002\u307e\u305f\u3001Benefit-harm\u3067\u306f\u306a\u304fBenefit-risk\u3042\u308b\u3044\u306fRisk-benefit\u3068\u3044\u3046\u7528\u8a9e\u304c\u7528\u3044\u3089\u308c\u308b\u5834\u5408\u3082\u3042\u308b\u3002<\/p>\n\n\n\n

\u30a2\u30a6\u30c8\u30ab\u30e01\uff5eT\u306e\u4e2d\u306e\u4e00\u3064\u3001\u30a2\u30a6\u30c8\u30ab\u30e0L\u306e\u52b9\u679c\u63a8\u5b9a\u5024\uff1d\u30ea\u30b9\u30af\u5dee\u306b\u3064\u3044\u3066\u3001\u6b63\u5473\u306e\u76caNB\u304c\u6b63\u8ca0\u9006\u8ee2\u3059\u308b\u95be\u5024\u306f\u3001\u6b63\u5473\u306e\u76ca\u304b\u3089\u30a2\u30a6\u30c8\u30ab\u30e0L\u306b\u3064\u3044\u3066\u3001Fk\u3001\u6a19\u6e96\u5316\u3057\u305f\u91cd\u8981\u5ea6\u3001\u30ea\u30b9\u30af\u5dee\u3092\u639b\u3051\u7b97\u3057\u305f\u5024\u3092\u5f15\u304d\u7b97\u3057\u3066\u3001\u6b63\u8ca0\u3092\u9006\u306b\u3057\u3001\u305d\u308c\u3092\u30a2\u30a6\u30c8\u30ab\u30e0L\u306e\u6a19\u6e96\u5316\u3057\u305f\u91cd\u8981\u5ea6wsl\u3067\u5272\u308a\u7b97\u3059\u308b\u3053\u3068\u3067\u6c42\u3081\u3089\u308c\u308b\u3002\u30a2\u30a6\u30c8\u30ab\u30e0L\u306b\u3064\u3044\u3066\u3001Fk\u3001\u6a19\u6e96\u5316\u3057\u305f\u91cd\u8981\u5ea6\u3001\u30ea\u30b9\u30af\u5dee\u3092\u639b\u3051\u7b97\u3057\u305f\u5024\u306f\u3001\u4ecb\u5165\u306b\u3088\u308a\u5f97\u3089\u308c\u308b\u5206\u306e\u52b9\u679c\u3092\u8868\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u95be\u5024\u3092\u6c42\u3081\u308b\u5834\u5408\u3001\u305d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u4ee5\u5916\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u30ea\u30b9\u30af\u5dee\u3068\u91cd\u8981\u5ea6\u306e\u5024\u306f\u540c\u3058\u306e\u307e\u307e\u3068\u3044\u3046\u3053\u3068\u304c\u524d\u63d0\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u30a2\u30a6\u30c8\u30ab\u30e0L\u306e\u91cd\u8981\u5ea6\u306b\u3064\u3044\u3066\u3001\u6b63\u5473\u306e\u76caNB\u304c\u6b63\u8ca0\u9006\u8ee2\u3059\u308b\u95be\u5024\u306f\u3001\u6b63\u5473\u306e\u76ca\u304b\u3089\u30a2\u30a6\u30c8\u30ab\u30e0L\u306b\u3064\u3044\u3066\u3001Fk\u3001\u6a19\u6e96\u5316\u3057\u305f\u91cd\u8981\u5ea6\u3001\u30ea\u30b9\u30af\u5dee\u3092\u639b\u3051\u7b97\u3057\u305f\u5024\u3092\u5f15\u304d\u7b97\u3057\u3066\u3001\u6b63\u8ca0\u3092\u9006\u306b\u3057\u3001\u305d\u308c\u3092\u30a2\u30a6\u30c8\u30ab\u30e0L\u306e\u30ea\u30b9\u30af\u5deeEijL\u3067\u5272\u308a\u7b97\u3059\u308b\u3053\u3068\u3067\u6c42\u3081\u3089\u308c\u308b\u3002\u3053\u306e\u5834\u5408\u3001\u4e0a\u8a18\u306e\u5834\u5408\u3068\u540c\u69d8\u3001\u305d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u4ee5\u5916\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u30ea\u30b9\u30af\u5dee\u3068\u91cd\u8981\u5ea6\u306e\u5024\u306f\u540c\u3058\u306e\u307e\u307e\u3068\u3044\u3046\u3053\u3068\u304c\u524d\u63d0\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\"\"
\u56f32\uff0e\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u52b9\u679c\u63a8\u5b9a\u5024 EijL\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6wL\u306e\u7bc4\u56f2\u3002<\/figcaption><\/figure>\n\n\n\n

\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u3001\u52b9\u679c\u63a8\u5b9a\u5024\uff08\u30ea\u30b9\u30af\u5dee\uff09\u306e\u7bc4\u56f2\u3001\u304a\u3088\u3073\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u306e\u7bc4\u56f2\u306f\u3001\u30a2\u30a6\u30c8\u30ab\u30e0L\u306b\u5bfe\u3059\u308b\u30ea\u30b9\u30af\u5deeEijL\u3068\u95be\u5024\u306e\u5927\u5c0f\u95a2\u4fc2\u304b\u3089\u5bb9\u6613\u306b\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff08\u56f32\uff09\u3002<\/p>\n\n\n\n

EijL\u306e\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u7bc4\u56f2\u306f\u3001EijL\u304c\u95be\u5024\u3088\u308a\u5927\u304d\u3051\u308c\u3070\u3001\u95be\u5024\u304b\u30891\u307e\u3067\u306e\u7bc4\u56f2\u304c\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u52b9\u679c\u63a8\u5b9a\u5024\uff08\u30ea\u30b9\u30af\u5dee\uff09\u306e\u7bc4\u56f2\u3068\u306a\u308b\u3002\u9006\u306b\u3001EijL\u304c\u95be\u5024\u3088\u308a\u5c0f\u3055\u3051\u308c\u3070\u3001-1\u304b\u3089\u95be\u5024\u307e\u3067\u306e\u7bc4\u56f2\u304c\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u52b9\u679c\u63a8\u5b9a\u5024\uff08\u30ea\u30b9\u30af\u5dee\uff09\u306e\u7bc4\u56f2\u3068\u306a\u308b\u3002<\/p>\n\n\n\n

\u3044\u305a\u308c\u306e\u5834\u5408\u3067\u3042\u308c\u3001\u3053\u306e\u7bc4\u56f2\u5916\u306e\u52b9\u679c\u63a8\u5b9a\u5024\u304c\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u3051\u308c\u3070\u3001\u30a2\u30a6\u30c8\u30ab\u30e0L\u306b\u5bfe\u3059\u308b\u52b9\u679c\u63a8\u5b9a\u5024\u304c\u5909\u52d5\u3057\u305f\u3068\u3057\u3066\u3082\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3059\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3068\u8003\u3048\u3066\u3044\u3044\u3053\u3068\u306b\u306a\u308b\u3002\u52b9\u679c\u63a8\u5b9a\u5024\u306e95\uff05\u4fe1\u983c\u533a\u9593\u3068\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u3001\u975e\u76f4\u63a5\u6027\u3001\u975e\u4e00\u8cab\u6027\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306a\u3069\u3092\u8003\u616e\u3057\u3066\u3082\u3001\u3053\u306e\u7bc4\u56f2\u5916\u306e\u5024\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u307b\u3068\u3093\u3069\u306a\u3044\u3068\u8a00\u3048\u308b\u304f\u3089\u3044\u4f4e\u3051\u308c\u3070\u3001\u305d\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u78ba\u5b9f\u6027\u306f\u9ad8\u3044\u3068\u5224\u65ad\u3067\u304d\u308b\u3002<\/p>\n\n\n\n

\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u306b\u3064\u3044\u3066\u306f\u3001\u30a2\u30a6\u30c8\u30ab\u30e0L\u306b\u5bfe\u3057\u3066\u8a2d\u5b9a\u3057\u305f\u91cd\u8981\u5ea6wL\u306e\u5024\u304c\u3001\u95be\u5024\u3088\u308a\u5927\u304d\u3044\u5834\u5408\u306f\u3001\u95be\u5024\u304b\u3089\uff08\u3082\u3057\u95be\u5024\u304c\u30de\u30a4\u30ca\u30b9\u306e\u5024\u306e\u5834\u5408\u306f0\u304b\u3089\uff09100\u307e\u3067\u306e\u7bc4\u56f2\u304c\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u306e\u7bc4\u56f2\u3068\u306a\u308b\u3002\u9006\u306b\u3001\u91cd\u8981\u5ea6wL\u304c\u95be\u5024\u3088\u308a\u5c0f\u3055\u3044\u5834\u5408\u306f\u30010\u304b\u3089\u95be\u5024\u307e\u3067\uff08\u3082\u3057\u95be\u5024\u304c100\u4ee5\u4e0a\u306e\u5834\u5408\u306f100\u307e\u3067\uff09\u306e\u7bc4\u56f2\u304c\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u7bc4\u56f2\u3068\u306a\u308b\u3002<\/p>\n\n\n\n

\u91cd\u8981\u5ea6\u306b\u3064\u3044\u3066\u3082\u3001\u3053\u306e\u7bc4\u56f2\u5916\u306e\u5024\u304c\u3042\u308a\u3048\u306a\u3044\u5024\u3068\u8003\u3048\u3089\u308c\u308b\u5834\u5408\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u3092\u5909\u52d5\u3055\u305b\u3066\u3082\u3001\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3059\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u7279\u306b\u3001\u52b9\u679c\u306e\u5927\u304d\u3055\u304c\u5c0f\u3055\u3044\u5834\u5408\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u7bc4\u56f2\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308b\u3002\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u306e\u5224\u5b9a\u306f\u500b\u4eba\u5dee\u304c\u3042\u308b\u304c\u3001\u305d\u306e\u632f\u308c\u5e45\u3092\u8003\u616e\u3057\u3066\u3082\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3059\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u3051\u308c\u3070\u3001\u5927\u90e8\u5206\u306e\u4eba\u306b\u9069\u7528\u3057\u3066\u3082\u4fa1\u5024\u89b3\u306e\u76f8\u9055\u306b\u3088\u308b\u554f\u984c\u306f\u8d77\u304d\u306a\u3044\u3067\u3042\u308d\u3046\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n\n\n\n

\u3053\u3053\u3067\u8ff0\u3079\u305f\u65b9\u6cd5\u306f\u3001\u201d\u95be\u5024\u5206\u6790 \u201cThreshold analysis\u201c\u3068\u547c\u3070\u308c(Phillippo DM 2019)\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u78ba\u5b9f\u6027\u306e\u8a55\u4fa1\u3001\u6b63\u5473\u306e\u76ca\u306e\u78ba\u5b9f\u6027\u306e\u8a55\u4fa1\u306b\u6709\u7528\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n\n

\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n

Gail MH, Costantino JP, Bryant J, Croyle R, Freedman L, Helzlsouer K, Vogel V: Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer. J Natl Cancer Inst 1999;91:1829-46. doi: 10.1093\/jnci\/91.21.1829 PMID: 10547390
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/10547390\/<\/a><\/p>\n\n\n\n

MCDA\u306b\u3064\u3044\u3066\u5e83\u304f\u89e3\u8aac\u3055\u308c\u3066\u3044\u308b\u3002Keeney & Raiffa\u306e\u65b9\u6cd5\u306e\u5b9f\u4f8b\u306e\u89e3\u8aac\u304c\u3042\u308b\u3002<\/p>\n\n\n\n

Thokala P, Devlin N, Marsh K, Baltussen R, Boysen M, Kalo Z, Longrenn T, Mussen F, Peacock S, Watkins J, Ijzerman M: Multiple Criteria Decision Analysis for Health Care Decision Making-An Introduction: Report 1 of the ISPOR MCDA Emerging Good Practices Task Force. Value Health 2016;19:1-13. PMID: 26797229
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/26797229\/<\/a><\/p>\n\n\n\n

\u4e0a\u8a18\u306eThokala P\u306e\u5831\u544a\u306e\u5f8c\u534a\u306b\u76f8\u5f53\u3057\u3001ISPOR\u306e\u516c\u5f0f\u306e\u5831\u544a\u3068\u3057\u3066\u51fa\u7248\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

Marsh K, IJzerman M, Thokala P, Baltussen R, Boysen M, Kalo Z, Lonngren T, Mussen F, Peacock S, Watkins J, Devlin N, ISPOR Task Force: Multiple Criteria Decision Analysis for Health Care Decision Making-Emerging Good Practices: Report 2 of the ISPOR MCDA Emerging Good Practices Task Force. Value Health 2016;19:125-37. PMID: 27021745
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/27021745\/<\/a><\/p>\n\n\n\n

\u52b9\u679c\u63a8\u5b9a\u5024\u306e\u4e0d\u78ba\u5b9f\u6027\u304b\u3089\u6b63\u5473\u306e\u76ca\u306e\u4e0d\u78ba\u5b9f\u6027\u3092\u63a8\u5b9a\u3059\u308b\u65b9\u6cd5\u3002<\/p>\n\n\n\n

Wen S, Zhang L, Yang B: Two approaches to incorporate clinical data uncertainty into multiple criteria decision analysis for benefit-risk assessment of medicinal products. Value Health 2014;17:619-28. PMID: 25128056
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/25<\/a>1<\/a>28056<\/a><\/p>\n\n\n\n

GRADE\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u306e\u76ca\u3068\u5bb3\u306e\u30d0\u30e9\u30f3\u30b9\uff1d\u6b63\u5473\u306e\u76ca\u306b\u95a2\u3059\u308b\u30b3\u30f3\u30bb\u30d7\u30c8\u30da\u30fc\u30d1\u30fc\u3002Certainty of net benefit\u3068\u3044\u3046\u8003\u3048\u306f\u3001USPSTF\u3068\u540c\u3058\u3067\u3001\u63a8\u5968\u306e\u5f37\u3055\u3092\u6c7a\u3081\u308b\u4e3b\u8981\u8981\u7d20\u3002Appendix\u306b\u5177\u4f53\u7684\u306a\u8a08\u7b97\u6cd5\u304c\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

Alper BS, Oettgen P, Kunnamo I, Iorio A, Ansari MT, Murad MH, Meerpohl JJ, Qaseem A, Hultcrantz M, Schunemann HJ, Guyatt G, GRADE Working Group: Defining certainty of net benefit: a GRADE concept paper. BMJ Open 2019;9:e027445. PMID: 31167868
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/31167868\/<\/a><\/p>\n\n\n\n

\u5b9a\u91cf\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u30fb\u30ea\u30b9\u30af\u5206\u6790\u306b\u95a2\u3059\u308bISPOR\u306e\u516c\u5f0f\u306e\u5831\u544a\u3002\u5b9f\u969b\u7684\u306a\u624b\u9806\u3092\u89e3\u8aac\u3002<\/p>\n\n\n\n

Tervonen T, Veldwijk J, Payne K, Ng X, Levitan B, Lackey LG, Marsh K, Thokala P, Pignatti F, Donnelly A, Ho M: Quantitative Benefit-Risk Assessment in Medical Product Decision Making: A Good Practices Report of an ISPOR Task Force. Value Health 2023;26:449-460. doi: 10.1016\/j.jval.2022.12.006 PMID: 37005055
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/37005055\/<\/a><\/p>\n\n\n\n

\u60a3\u8005\u306e\u55dc\u597d\u3092\u53d6\u308a\u5165\u308c\u308b\u305f\u3081\u306e\u67a0\u7d44\u307f\u306b\u95a2\u3059\u308b\u3001\u898f\u5236\u5f53\u5c40\u306e\u30b3\u30f3\u30bd\u30fc\u30b7\u30a2\u30e0\u306e\u5831\u544a\u66f8\u3002\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6\u3092\u6c7a\u3081\u308b\u69d8\u3005\u306a\u65b9\u6cd5\u306e\u30ea\u30b9\u30c8\u304c\u3042\u308b\u3002<\/p>\n\n\n\n

Ho M, Saha A, McCleary KK, Levitan B, Christopher S, Zandlo K, Braithwaite RS, Hauber AB, Medical Device Innovation Consortium\u2019s Patient Centered Benefit-Risk Steering Committee: A Framework for Incorporating Patient Preferences Regarding Benefits and Risks into Regulatory Assessment of Medical Technologies. Value Health 2016;19:746-750. PMID: 27712701
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/27712701\/<\/a><\/p>\n\n\n\n

Phillippo DM, Dias S, Welton NJ, Caldwell DM, Taske N, Ades AE: Threshold Analysis as an Alternative to GRADE for Assessing Confidence in Guideline Recommendations Based on Network Meta-analyses. Ann Intern Med 2019;170:538-546. doi: 10.7326\/M18-3542 PMID: 30909295
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/30909295\/<\/a><\/p>\n\n\n\n

Eiring \u00d8, Brurberg KG, Nytr\u00f8en K, Nylenna M: Rapid methods including network meta-analysis to produce evidence in clinical decision support: a decision analysis. Syst Rev 2018;7:168. doi: 10.1186\/s13643-018-0829-z PMID: 30342549
URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/30342549\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

T\u500b\u306e\u4ecb\u5165\u304c\u3042\u308b\u3068\u3057\u3001\u4ecb\u5165i\u306e\u52b9\u679c\u3092\u4ecb\u5165j\u3059\u306a\u308f\u3061\u5bfe\u7167\u3068\u6bd4\u8f03\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067K\u500b\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c\u30ea\u30b9\u30af\u5dee\u3067\u5f97\u3089\u308c\u305f\u3068\u3059\u308b\u3002\u305d\u3053\u3067\u3001\u30da\u30a2\u3067\u6b63\u5473\u306e\u76ca\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3059\u308b\u3002\uff08i, j, T, K, L\u306f\u6574\u6570\uff09\u3002 … “\u6b63\u5473\u306e\u76ca\u304c\u53cd\u8ee2\u3057\u306a\u3044\u95be\u5024\uff1a\u52b9\u679c\u63a8\u5b9a\u5024\u3068\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u91cd\u8981\u5ea6” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,3,6],"tags":[],"class_list":["post-1538","post","type-post","status-publish","format-standard","hentry","category-benefit-harm-assessment","category-mdm","category-sdm"],"_links":{"self":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/1538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1538"}],"version-history":[{"count":6,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/1538\/revisions"}],"predecessor-version":[{"id":1547,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=\/wp\/v2\/posts\/1538\/revisions\/1547"}],"wp:attachment":[{"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/info.zanet.biz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}